Pathology

Download e-book for iPad: Amyloid and Related Disorders: Surgical Pathology and by Maria M. Picken MD PhD FASN, Ahmet Dogan, Guillermo A.

By Maria M. Picken MD PhD FASN, Ahmet Dogan, Guillermo A. Herrera

ISBN-10: 3319192930

ISBN-13: 9783319192932

ISBN-10: 3319192949

ISBN-13: 9783319192949

The moment variation of this article provides an outline of the newest advancements during this sector together with medical presentation, etiology, pathogenesis, and differential analysis. the reason for numerous cures, together with transplantation, is mentioned and tissue prognosis (its pitfalls and methods for averting them) and laboratory help are integrated. The involvement of all significant organ structures together with renal/genitourinary, cardiac, gastrointestinal, pulmonary, peripheral nerve/central anxious method, gentle tissue, epidermis, lymph node/spleen and bone marrow pathology can also be covered.

Amyloid and similar issues, moment Edition should be necessary to really expert and basic pathologists in addition to cytopathologists. different doctors can also make the most of this concise replace at the systemic amyloidoses.

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Extra info for Amyloid and Related Disorders: Surgical Pathology and Clinical Correlations

Sample text

When peripheral neuropathy is the dominant syndrome, a differential diagnosis between AL and hereditary amyloidosis becomes mandatory. The presence of amyloid autonomic neuropathy manifests as postural hypotension, erectile dysfunction and gastrointestinal symptoms (constipation, diarrhoea or an alternation thereof). The latter symptoms can also be the consequence of amyloid deposition within the gastrointestinal tract, which is clinically evident in less than 10 % of cases. Other sites of amyloid deposition, including cutis, muscle, respiratory tract, genitourinary system and lymph nodes, are less commonly documented.

Abstr. 2796. 104. Kumar S, et al. A novel prognostic staging system for light chain amyloidosis (AL) incorporating markers of plasma cell burden and organ involvement. Blood. 2009;114. abstr. 2797. 105. Merlini G, Seldin DC, Gertz MA. Amyloidosis: pathogenesis and new therapeutic options. J Clin Oncol. 2011;29:1924–33. 106. Comenzo RL, et al. Mobilized CD34+ cells selected as autografts in patients with primary light-chain amyloidosis: rationale and application. Transfusion. 1998;38:60–9. 107. Fonseca R, et al.

However, as soon as a critical nucleus has been generated, fibril formation begins and further proceeds with very fast kinetics: any amyloidogenic precursor in its aggregation-prone conformation is rapidly incorporated into the growing fibrils [1, 5, 62]. Moreover, fragmentation of growing fibrils and other nucleation events further accelerate amyloidogenesis [63]. The seeding mechanism may have clinical implications, since the process of amyloid resorption, following a positive response to therapy, usually leaves the seeds in tissues.

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Amyloid and Related Disorders: Surgical Pathology and Clinical Correlations by Maria M. Picken MD PhD FASN, Ahmet Dogan, Guillermo A. Herrera


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