Biochemistry

M L Anson; John T Edsall's Advances in protein chemistry. / Volume PDF

By M L Anson; John T Edsall

ISBN-10: 0120342014

ISBN-13: 9780120342013

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The subfibril seems to be a unit of structure a t this level of organization t,hough it is no doubt composed of still finer columnar units; occasionally finer strands are seen, and it is supposed that the cleavage was due to some unrecognized factor in the chemical environment. It is an interesting commentary that Ballowita (1890) observed the fraying of many types of sperm tails into subfibrils, made visible microscopically no doubt, by adsorption of stains. Fig. 1 Fig. 2 Fig. 1 . Frayed tail of bull sperm showing subfibrils.

63 INTRODUCTION Proteins antl coinplexes of proteins with lipids and ctlridiytlrit 1 ::s form the basis of the structural components of cells and tissue:;. Jl'ilf~r~ ;is these structural proteins have, in the past,, becn invcstigated chiefly by the techniques of classical morphology, advances during thc. lnst two decades in thc chemistry of these complex molccules antl in physical techniques for investigating their internal nrchitectiire have laid thc foiinJxtion fo:. new correlations between structure and function.

Hoerr believes that Claude’s ‘secretory granule’ fraction really contains mitochondria. Further work is required to establish the reasons for these disagreements, Lazarow (1943) and Barron (1943) discuss the r61e of mitochondria and microsomes as carriers for enzymes involved in cellular metabolism. (1 BTRUCPORAL PROTEINS OF CELLS AND "ISSUES 31 R6k of Protein Particulates in Cellular Enzyme Reactions. In addition to the components mentioned above, various high molecular weight particles having enzymic activity have been isolated (see particularly Stern, 1939, 1943; Korr, 1939; Henle and Chambers, 1940; and Iiabat, 1941).

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Advances in protein chemistry. / Volume by M L Anson; John T Edsall


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