By Alton Meister
Advances in Enzymology and similar components of Molecular Biology is a seminal sequence within the box of biochemistry, supplying researchers entry to authoritative reports of the newest discoveries in all parts of enzymology and molecular biology. those landmark volumes date again to 1941, supplying an unequalled view of the historic improvement of enzymology. The sequence bargains researchers the most recent realizing of enzymes, their mechanisms, reactions and evolution, roles in advanced organic technique, and their program in either the laboratory and undefined. every one quantity within the sequence positive aspects contributions by way of top pioneers and investigators within the box from worldwide. All articles are rigorously edited to make sure thoroughness, caliber, and clarity.
With its wide selection of issues and lengthy historic pedigree, Advances in Enzymology and comparable parts of Molecular Biology can be utilized not just through scholars and researchers in molecular biology, biochemistry, and enzymology, but in addition by means of any scientist attracted to the invention of an enzyme, its homes, and its applications.
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Extra resources for Advances in Enzymology and Related Areas of Molecular Biology, Volume 53
However, the additional distinction of the nucleotide regulatory protein as a separate component and as a part of the high-affinity receptor ternary complex requires even more complex models, as indicated in Figure 5 . A closely related model proposed by Tolkovsky et al. (1 14-1 15), the “collision coupling model,” describes a transient and rate-limiting reaction of the hormone-receptor complex HR with the enzyme E. This model is in agreement with the observation that the active form of the catalytic unit incorporates the nucleotide binding protein but not the receptor component itself.
Sci. , 76, 5475 (1979). 159. Lefkowitz, R. , and Stadel, J. , Current Topics in Cellular Regulation, 17, 205 (1980). Advances in Enzymology and Related Areas of Molecular Biology, Volume 53 Edited by Alton Meister Copyright © 1982 by John Wiley & Sons, Inc. 6-B I S PH 0 S PH A T A S E By STEPHEN J. BENKOVIC and MARGARET M. deMAINE, Departnient of Cliernistry, The Peririsylvania State University, University Park, Pennsylvania CONTENTS I. Introduction 11. Physical Properties A. Structural Properties B.
Shiu, R. , and Friesen, H. G . , J . Biol. , 249, 7902 (1974). 15. Caron, M. , and Lefkowitz, R. , J. Biol. , 254, 2923 (1979). 16. Vauquelin, G . , and Strosberg, A. , Proc. Natl. Acad. Sci. , 74, 3710 (1977). 17. (a) Limbird, L. , and Lefkowitz, R. , Mol. , 12, 559 (1976); (b) Robert G. , Shorr, Marc G. Caron, and Robert J. Lefkowitz, unpublished data. 18. Lefkowitz, R. , and Caron, M. , Biochem. Biophys. Res. , 60, 703 (1974). 19. Aurbach, G. , Sedak, S. , Woodard, C. , Palmer, J. , Science, 186, 1223 (1974).
Advances in Enzymology and Related Areas of Molecular Biology, Volume 53 by Alton Meister