By Robert Lev
Adenomatous Polyps of the Colon: Pathobiological and Clinical Features consolidates the immense physique of uncomplicated technological know-how and medical information linked to adenomatous polyps of the colon, a lot of it encouraged by means of the belief that almost all colorectal carcinomas appear to come up in such polyps. This publication strives to judge those information, with specific emphasis on their implications for administration of polyp-bearing matters. issues comprehensively explored contain anatomy and histology of the traditional colon; pathologic features of adenomatous polyps, differential prognosis, and grading schemes for measure of dysplasia and villosity; adenomatous polyposes; histologic and epidemiologic facts for the malignant strength of adenomatous polyps; and detection and administration, with specific realization to endoscopy, endoscopic polypectomy, the malignant polyp, and post-polypectomy surveillance schedules.
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Adenomatous Polyps of the Colon: Pathobiological and scientific beneficial properties consolidates the gigantic physique of simple technology and scientific facts linked to adenomatous polyps of the colon, a lot of it encouraged by way of the belief that almost all colorectal carcinomas appear to come up in such polyps. This ebook strives to judge those info, with specific emphasis on their implications for administration of polyp-bearing matters.
While different textbooks combine a scientific technique with quite a lot of the fundamental technological know-how of gastroenterology, this e-book concentrates on supplying training gastroenterologists with a hundred% clinically targeted, evidence-based chapters on tips on how to effectively analysis and deal with all problems of the digestive tract.
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Extra info for Adenomatous Polyps of the Colon: Pathobiological and Clinical Features
J Pediatr Gastroenterol Nutr 6:414-425. Lipkin M (1974) Phase I and phase II proliferative lesions of colonic epithelial cells in diseases leading to colonic cancer. Cancer 34:878-888. Lipkin M, Bell B, Sherlock P (1963) Cell proliferation kinetics in the gastrointestinal tract of man. I. Cell renewal in colon and rectum. J Clin Invest 42:767-776. Makela V, Korhonen LK, Lilus G (1971) Carbohydrate-rich compounds in the colonic mucosa of man. Cancer 27:120-127. Mariani-Costantini R, Theillet C, Hutzell P, Merlo G, Schlom J, Callahan R (1989) In situ detection of c-myc mRNA in adenocarcinomas, adenomas, and mucosa of human colon.
Hamartomatous Polyps Various hamartomatous conditions may involve the colon, but only the most common of these, the Peutz-Jeghers syndrome, will be discussed here. This disease, which is transmitted as an autosomal dominant, is characterized by hamartomatous polyps of the gastrointestinal tract, mucocutaneous pigmentation, and a variety of extraintestinal disorders (Dormandy, 1957). The polyps predominate in the small intestine but may also be found in the colon. They consist of irregular aggregates of nonneoplastic glands separated by smooth muscle bundles.
Dis Colon Rectum 24:331-342. Enterline HT (1976) Polyps and cancer of the large bowel. In B Morson (ed): Current Topics in Pathology: Vul 63. Pathology of the Gastrointestinal Tract. Springer-Verlag, Berlin, pp 95-141. Enterline HT, Arvan DA (1967) Chromosome constitution of adenoma and adenocarcinoma of the colon. Cancer 20:1746-1759. Estrada R, Spjut H (1980) Hyperplastic polyps of the large bowel. Am J Surg Pathol 4:127-133. Fearon ER, Hamilton SR, Vogelstein B (1987) Clonal analysis of human colorectal tumors.
Adenomatous Polyps of the Colon: Pathobiological and Clinical Features by Robert Lev